Caffeine-Induced Taste Aversions In Lewis And Fischer Rat Strains: Differential Sensitivity To The Aversive Effects of Drugs

Aladin Research Commons

Caffeine-Induced Taste Aversions In Lewis And Fischer Rat Strains: Differential Sensitivity To The Aversive Effects of Drugs

Show simple item record

dc.contributor.advisor Riley, Anthony L en_US
dc.contributor.author Vishwanath, Janani Meenakshi en_US
dc.contributor.other Gomez-Serrano, Maria en_US
dc.contributor.other Parker, Scott en_US
dc.date.accessioned 2012-08-22T15:01:39Z
dc.date.available 2012-08-22T15:01:39Z
dc.date.created 2011 en_US
dc.date.issued 2012-08-22
dc.identifier.other Vishwanath_american_0008N_10127 en_US
dc.identifier.uri http://hdl.handle.net/1961/11135
dc.description Degree awarded: M.A. Psychology. American University en_US
dc.description.abstract Lewis (LEW) and Fischer 344 (F344) rat strains have been reported to differ in the aversive effects induced by a number of drugs. The present studies extended this previous work and examined the ability of caffeine to induce taste aversions in the two strains. Specifically, LEW and F344 rats were given access to saccharin and injected with varying doses of caffeine (0, 0.32, 1.0 and 3.2 mg/kg - Experiment 1; 0, 10, 18 and 32 mg/kg - Experiment 2). Additionally, the effects of caffeine on locomotor activity were examined in Experiment 2. At low doses (Experiment 1), caffeine failed to induce taste aversions in either strain. At higher doses (Experiment 2), aversions were induced that were strain dependent. Specifically, caffeine induced taste aversions in both strains at 32 mg/kg, while 18 mg/kg caffeine was effective in inducing aversions only in the LEW strain. Caffeine increased activity in both strains with no strain difference. This demonstration adds to the growing list of drugs on which the LEW and F344 strains differ in relation to their affective properties. Given that drug use and abuse is a function of the balance of the rewarding and aversive effects of drugs, understanding such strain differences may provide insight into the biological (and genetic) factors impacting abuse vulnerability. en_US
dc.format.extent 34 p. en_US
dc.format.mimetype application/pdf en_US
dc.publisher American University en_US
dc.subject Psychology en_US
dc.subject.other Caffeine en_US
dc.subject.other Fischer en_US
dc.subject.other Lewis en_US
dc.subject.other Locomotor Activity en_US
dc.subject.other Rat en_US
dc.subject.other Taste Aversion en_US
dc.title Caffeine-Induced Taste Aversions In Lewis And Fischer Rat Strains: Differential Sensitivity To The Aversive Effects of Drugs en_US
dc.type Text en_US
dc.type Dissertation en_US


Files in this item

Files Size Format View
Vishwanath_american_0008N_10127display.pdf 630.9Kb PDF View/Open

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account

Statistics