SYNTHESIS AND APPLICATION OF FLUORESCENTLY LABELED MONOCYCLIC THIO-ß-LACTAM DERIVITIVES

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SYNTHESIS AND APPLICATION OF FLUORESCENTLY LABELED MONOCYCLIC THIO-ß-LACTAM DERIVITIVES

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Title: SYNTHESIS AND APPLICATION OF FLUORESCENTLY LABELED MONOCYCLIC THIO-ß-LACTAM DERIVITIVES
Author: Schultz, Victor Leatherman
Abstract: Novel methodologies for the synthesis of fluorescently labeled monobactam derivatives were developed and explored. Two separate ß-lactam derivatives, 4-(4 aminophenylthio)azetidin-2-one and 4-phenylsulflanyl-azetidin-2-one were labeled with several combinations of fluorophores and electron withdrawing groups allowing for these drugs to be observed within a living bacterial cell. Observation of the drugs in vivo will provide valuable information as to the structure activity relationship and exact mechanism of action of these compounds.
Description: Degree awarded: M.S. Chemistry. American University
URI: http://hdl.handle.net/1961/11108
Date: 2012-08-22


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