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SYNTHESIS AND APPLICATION OF FLUORESCENTLY LABELED MONOCYCLIC THIO-ß-LACTAM DERIVITIVES

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posted on 2023-09-07, 02:01 authored by Victor Leatherman Schultz

Novel methodologies for the synthesis of fluorescently labeled monobactam derivatives were developed and explored. Two separate ß-lactam derivatives, 4-(4 aminophenylthio)azetidin-2-one and 4-phenylsulflanyl-azetidin-2-one were labeled with several combinations of fluorophores and electron withdrawing groups allowing for these drugs to be observed within a living bacterial cell. Observation of the drugs in vivo will provide valuable information as to the structure activity relationship and exact mechanism of action of these compounds.

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Publisher

American University

Notes

Degree awarded: M.S. Chemistry. American University

Handle

http://hdl.handle.net/1961/11108

Degree grantor

American University. Department of Chemistry

Degree level

  • Masters

Submission ID

10038

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