EFFECT OF ETHER GROUPS ON THE STRUCTURE ACTIVITY RELATIONSHIP (SAR) OF NOVEL ANTIMICROBIAL COMPOUNDS

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EFFECT OF ETHER GROUPS ON THE STRUCTURE ACTIVITY RELATIONSHIP (SAR) OF NOVEL ANTIMICROBIAL COMPOUNDS

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Title: EFFECT OF ETHER GROUPS ON THE STRUCTURE ACTIVITY RELATIONSHIP (SAR) OF NOVEL ANTIMICROBIAL COMPOUNDS
Author: Minah, Jeanette Tewoh
Abstract: Bacterial resistance to antibiotic treatment has become a major problem over the years originating from penicillin binding proteins, efflux pumps and the major contributor, beta-lactamases. Therefore, a need arises for developing new antimicrobial drugs, with a different mechanism of action, in-order to delay further bacterial resistance. Examples of such compounds prepared in our research group comprise of monocyclic β-lactams with distinct substituent groups attached to an aromatic thiol, at the C4 of the beta-lactam. These compounds, especially fluorinated thiophenols in the ortho position with the addition of benzyl isocyanate on the lactam nitrogen demonstrate activity against lipo-oliogosaccharide-containing bacteria, specifically Mycobacterium tuberculosis (Mtb). The focus of my research is to create a library of derivatives of these lactams with methoxy groups attached at various positions of the aromatic ring at C4 in-order to evaluate their activity against the aforementioned bacteria. SAR of these ether-containing-lactams against Mtb will be discussed.
Description: Degree awarded: M.S. Chemistry. American University
URI: http://hdl.handle.net/1961/11081
Date: 2012-08-22


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