STRUCTURE ACTIVITY RELATIONSHIP (SAR) OF FLUORINATED AND CARBAMYLATED BETA-LACTAM DERIVATIVES

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STRUCTURE ACTIVITY RELATIONSHIP (SAR) OF FLUORINATED AND CARBAMYLATED BETA-LACTAM DERIVATIVES

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dc.contributor.advisor Konaklieva, Monika en_US
dc.contributor.author Lloyd, Dina en_US
dc.contributor.other Fox, Douglas en_US
dc.contributor.other Girard, James en_US
dc.date.accessioned 2012-08-22T15:01:15Z
dc.date.available 2012-08-22T15:01:15Z
dc.date.created 2011 en_US
dc.date.issued 2012-08-22
dc.identifier.other Lloyd_american_0008M_10030 en_US
dc.identifier.uri http://hdl.handle.net/1961/11070
dc.description Degree awarded: M.S. Chemistry. American University en_US
dc.description.abstract While drug-resistance exists in a wide range of clinically important microorganisms, new drug development has significantly lagged behind the need. We are directly addressing this gap in antimicrobial development by synthesizing a novel class of antimicrobials that are not inactivated by the microbial beta-lactamases. To date, we have synthesized cadres of compounds with demonstrated good activity (minimum inhibitory (MIC) and minimum bactericidal concentration, MBC, <15 ug/ml) against Mycobacterium tuberculosis (Mtb) or Moraxella catarrhalis (M.cat.). The focus of my research is to prepare a second generation of these drugs by building a library of compounds containing fluorinated derivatives. The position and multitude of the fluorine atoms in the compounds' scaffold is expected to improve overall efficacy of these compounds. In addition, preparation of compounds with differently substituted carbamyl groups has been accomplished. The Structure Activity Relationship (SAR) of these two types of compounds will be presented. en_US
dc.format.extent 74 p. en_US
dc.format.mimetype application/pdf en_US
dc.publisher American University en_US
dc.subject Chemistry en_US
dc.subject.other beta-Lactam en_US
dc.subject.other beta-Lactamases en_US
dc.subject.other Fluorine en_US
dc.title STRUCTURE ACTIVITY RELATIONSHIP (SAR) OF FLUORINATED AND CARBAMYLATED BETA-LACTAM DERIVATIVES en_US
dc.type Text en_US
dc.type Dissertation en_US


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